重组人 CXCL10 / Crg-2 蛋白|Chemokine (C-X-C motif) ligand 10 Protein|产品详情|价格

CXCL10 / Crg-2蛋白产品信息
产品名称：重组人 CXCL10 / Crg-2 蛋白|Chemokine (C-X-C motif) ligand 10 Protein|产品详情|价格
别名: CXCL10, INP10, SCYB10
表达方式: A DNA sequence encoding the mature form of human CXCL10  (Q9UBH0) (Val22-Pro98) was expressed, with a N-terminal Met.
种属: Human
表达宿主: E.coli

CXCL10 / Crg-2 Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CXCL10  consists of  78 amino acids and predicts a molecular mass of 8.8 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL10 / Crg-2 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL10 / Crg-2蛋白背景综述
CXCL10, also known as crg-2, belongs to the intercrine alpha (chemokine CxC) family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. With a three-dimensional crystal structure, CXCL10’s signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. It is secreted by monocytes, epithelial cells, and endothelial cells in response to IFN gamma or other pro-inflammatory cytokines and stimuli. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4.
参考文献
O'Donovan N. et al., 1999, Cell Genet. 84 (1-2): 39-42.
Swaminathan GJ. et al., 2003, Structure. 11 (5): 521-32.
Booth V. et al., 2002, Biochemistry. 41 (33): 10418-25.

包装：50ug

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