重组人 CCL1 / I-309 / TCA3 蛋白|Chemokine (C-C motif) ligand 1 Protein|技术资料|报价

CCL1 / I-309 / TCA3蛋白产品信息
产品名称：重组人 CCL1 / I-309 / TCA3 蛋白|Chemokine (C-C motif) ligand 1 Protein|技术资料|报价
别名: CCL1, SCYA1
表达方式: A DNA sequence encoding the human CCL1 (P22362) (Lys24-Lys96) was expressed, with a N-terminal Met.
种属: Human
表达宿主: E.coli

CCL1 / I-309 / TCA3 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CCL1 consists of  75 amino acids and predicts a molecular mass of 8.7 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 40% acetonitrile, 0.1%TFA 20% H2O.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CCL1 / I-309 / TCA3 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL1 / I-309 / TCA3蛋白背景综述
Chemokines are a family of structurally related leukocyte chemoattractant cytokines that play a central role during immunoregulatory and inflammation processes. All chemokines contain four conserved cysteines linked by disulfide bonds, and two major subfamilies, namely CXC and CC, are defined on the basis of the first two cysteines which are separated by one amino acid or are adjacent. Human CCL1, also well known as I-309, is a small glycoprotein (73 amino acid residue as mature form) secreted by activated T lymphocytes. Human I-309 is assumed to be homologous to the mouse TCA-3 despite of the only approximately 42% amino acid sequence identity. CCL1 interacts with the G protein-linked transmembrane chemokine receptors CCR8, and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that CCL1 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, CCL1 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection.
参考文献
Miller MD. et al., 1992, Proc Natl Acad Sci. 89: 2950-4.
Roos RS. et al., 1997, J Biol Chem. 272: 17251-4.
Bernardini G. et al., 2000, Blood. 96: 4039-45.
Horuk R. et al., 1998, J Biol Chem. 273: 386-91.
Spinetti G. et al., 2003, J Leuko Biol. 73: 201-7.

包装：10ug

1、产品质量问题，在产品售出7日内提出异议并且产品未有损坏，试剂类产品，需要提供详细的检测数据，创赛负责免费退换货服务；
2、本产品属于消耗品，不提供质保服务；
3、所有产品售后问题，请直接联系我司，我们将会尽快为您响应处理
查询关键词：重组人 CCL1 / I-309 / TCA3 蛋白|,Chemokine (C-C motif) ligand 1 Protein,技术资料,报价，原料药，大包装定制，现货促销，医药中间体，科学仪器，实验室耗材，生化试剂，创赛中国,细胞因子
CANSPEC品质提供的重组人 CCL1 / I-309 / TCA3 蛋白|Chemokine (C-C motif) ligand 1 Protein|技术资料|报价性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com或www.4006087598.com