重组食蟹猴 CCL17 / TARC 蛋白|Chemokine (C-C motif) ligand 17 Protein|技术资料|参数

CCL17 / TARC蛋白产品信息
产品名称：重组食蟹猴 CCL17 / TARC 蛋白|Chemokine (C-C motif) ligand 17 Protein|技术资料|参数
别名: CCL17, TARC
表达方式: A DNA sequence encoding the cynomolgus CCL17 (Q8HYP9) (Met1-Ser94) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Baculovirus-Insect cells

CCL17 / TARC Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 24
分子量: The recombinant heterodimer of cynomolgus CCL17 comprises 81 amino acids and has a calculated molecular mass of 9.5 KDa. The apparent molecular mass of the protein is approximately 10 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile 20mM Tris, 500mM NaCl,  pH 7.4, 10% gly.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CCL17 / TARC Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL17 / TARC蛋白背景综述
C-C motif chemokine 17, also known as CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17 and SCYA17, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. CCL17 / SCYA17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts. CCL17 / SCYA17 is expressed at high levels in thymus and at low levels in the lung, colon and small intestine. CCL17 / SCYA17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. It may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. CCL17 / SCYA17 binds to CCR4.Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune disease.
参考文献
Belperio JA. et al., 2004, J Immunol. 173 (7): 4692-8.
Carpenter KJ. et al., 2005, Infect Immun. 73 (11): 7198-207.
Saeki H. et al., 2006, J Dermatol Sci. 43 (2): 75-84.
Niens M. et al., 2008, Br J Haematol. 140 (5): 527-36.
Stutte S. et al., 2010, Proc Natl Acad Sci. 107 (19): 8736-41.

包装：20ug

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