重组狗 CXCL13 / BCA-1 蛋白|Chemokine (C-X-C motif) ligand 13 Protein|技术资料|参数

CXCL13 / BCA-1蛋白产品信息
产品名称：重组狗 CXCL13 / BCA-1 蛋白|Chemokine (C-X-C motif) ligand 13 Protein|技术资料|参数
别名: CXCL13
表达方式: A DNA sequence encoding the canine CXCL13 (XP_851619.3) (Val23-Asn110) was expressed with a N-terminal polyhistidine tag.
种属: Canine
表达宿主: E.coli

CXCL13 / BCA-1 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: The recombinant canine CXCL13 comprises 104 amino acids and has a predicted molecular mass of 12.1 kDa. The apparent molecular mass of the protein is approximately 15 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL13 / BCA-1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CXCL13 / BCA-1蛋白背景综述
CXCL13, also known as BCA-1 ( B-cell-attracting chemokine-1 ) or BLC ( B-lymphocyte chemoattractant ), is a major regulator of B-cell trafficking. CXCL13 is a small cytokine belonging to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. The increased level of CXCL13 is a feature of systemic lupus erythematosus (SLE) that correlates with disease activity. Furthermore, CXCL13 might be a readily available surrogate marker to monitor the extent of aberrant B-cell (dys-)function. The vascular endothelial BCA-1 expression may be consequent to transcytosis. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). CXCL13 expression is a distinctive feature of angioimmunoblastic T-cell lymphoma, providing further support for the germinal center T-helper cell as the cell of origin for this neoplasm. Furthermore, CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.
参考文献
Ansel KM. et al., 2000, Nature. 406 (6793): 309-14.
Schiffer L. et al., 2009, Nephrol Dial Transplant. 24 (12): 3708-12.
Rupprecht TA. et al., 2009, J Neuroinflammation. 6: 42.
Smith JR. et al., 2003, Blood. 101 (3): 815-21.
Grogg KL. et al., 2006, Mod Pathol. 19 (8): 1101-7.
Falkenhagen KM. et al., 2005, Am J Ophthalmol. 140 (2): 335-7.

包装：20ug

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