重组人 LRP10 蛋白|Low density lipoprotein receptor-related protein 10 Protein|生产厂家|价

LRP10蛋白产品信息
产品名称：
别名: MSTP087, LRP9, MST087
表达方式: A DNA sequence encoding the human LRP10 (Q7Z4F1-1) extracellular domain (Met 1- Lys 440) was fused with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

LRP10蛋白质控指标
纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His 17
分子量: The secreted recombinant human LRP10 consists of 435 amino acids and has a predicted molecular mass of 47.5 kDa. The apparent molecular mass of rhLRP10 is approximately 60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
LRP10蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LRP10蛋白背景综述
Low-density lipoprotein receptor-related protein 10 (LRP10) is one member of the Low-density lipoprotein receptorrelated protein family. LRP10 plays an important role in lipoprotein metabolism. Chylomicron remnants, produced by lipolysis, are rapidly taken up by the liver via an apolipoprotein E (apoE)-mediated, receptor-dependent process. The low density lipoprotein (LDL) receptor-related protein (LRP) has been suggested as the potential apoE receptor. low density lipoprotein (LDL) receptor-related protein (LRP) 10 (LRP10) inhibits the canonical Wnt / beta- catenin signaling pathway. The beta-catenin/T cell factor (TCF) transcriptional activity in HEK293 cells was activated by transfection with Wnt3a or LRP6, which was then inhibited by co-transfection with LRP10. Deletion of the extracellular domain of LRP10 negated its inhibitory effect. It sugested that LRP10 may interfere with the formation of the beta-catenin/TCF complex and its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway. LRP10 has been improved to play a significant role in the brain physiology other than lipoprotein metabolism.
参考文献
Jeong YH. et al., 2010, Biochem Biophys Res Commun. 392 (4): 495-9.
Beisiegel U. et al., 1991, Proc Natl Acad Sci. 88 (19): 8342-6.
Strickland DK. et al., 1990, J Biol Chem. 265 (29): 17401-4.

包装：20ug

1、产品质量问题，在产品售出7日内提出异议并且产品未有损坏，试剂类产品，需要提供详细的检测数据，创赛负责免费退换货服务；
2、本产品属于消耗品，不提供质保服务；
3、所有产品售后问题，请直接联系我司，我们将会尽快为您响应处理
查询关键词：重组人 LRP10 蛋白,Low density lipoprotein receptor-related protein 10 Protein,生产厂家,价格，原料药，大包装定制，现货促销，医药中间体，科学仪器，实验室耗材，生化试剂，创赛中国,细胞因子
CANSPEC品质提供的重组人 LRP10 蛋白|Low density lipoprotein receptor-related protein 10 Protein|生产厂家|价格性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com或www.4006087598.com