重组甲型流感 H12N1 (A/mallard duck/Alberta/342/1983) 血凝素 (Hemagglutinin / HA) 蛋白|价格

H12N1(A/mallard duck/Alberta/342/1983) HA蛋白产品信息
产品名称：重组甲型流感 H12N1 (A/mallard duck/Alberta/342/1983) 血凝素 (Hemagglutinin / HA) 蛋白|价格
别名: HA
表达方式: A DNA sequence encoding the extracellular domain of influenza A virus hemagglutinin (A/mallard duck/Alberta/342/1983(H12N1))（ABB88099.1）(Met 1-Lys 527) was fused with a polyhistidine tag at the C-terminus.
种属: Influenza A Virus
表达宿主: Human Cells
H12N1(A/mallard duck/Alberta/342/1983) HA蛋白质控指标

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 18
分子量: The secreted recombinant hemagglutinin of influenza A H12N1 HA (A/mallard duck/Alberta/342/1983(H12N1)) comprises 521 amino acids and has a predicted molecular mass of 59.3 kDa. As a result of glycosylation, it migrates as an approximately 85 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

H12N1(A/mallard duck/Alberta/342/1983) HA蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

H12N1(A/mallard duck/Alberta/342/1983) HA蛋白背景综述
Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence.
参考文献
Barman S. et al., 2000, J Virol. 74: 6538-45.
Suzuki T. et al., 2005, J Virol. 79: 11705-15.
Shinya K. et al., 2006, Nature. 440 (7083): 435-6.
Marjuki H. et al., 2006, J Biol Chem. 281: 16707-15.
Christophe F. et al., 2009, Science. 324:1557-61.
Von Itzstein M. 2007, Nat Rev Drug Discov. 6: 967-74.

包装：50ug

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