重组小鼠 NLGN1 / Neuroligin-1 蛋白|Neuroligin 1 Protein| 生产厂家|现货

NLGN1 / Neuroligin-1蛋白产品信息
产品名称：重组小鼠 NLGN1 / Neuroligin-1 蛋白|Neuroligin 1 Protein| 生产厂家|现货
别名: 6330415N05Rik, BB179718, NL1, Mkiaa1070
表达方式: A DNA sequence encoding the mouse NLGN1 isoform 1(Q99K10-1) extracellular domain (Met 1-Ser 697) was expressed, with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

NLGN1 / Neuroligin-1蛋白质控指标
纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 46
分子量: The recombinant mouse NLGN1 consists of 671 amino acids and predicts a molecular mass of 73.5 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmNLGN1 is approximately 100-110 KDa as a result of glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
NLGN1 / Neuroligin-1蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NLGN1 / Neuroligin-1蛋白背景综述
Neuroligin-1, also known as NLGN1, is a single-pass type I  membrane protein which belongs to the type-B carboxylesterase / lipase family. Neuroligins are cell-adhesion molecules located at the postsynaptic side of the synapse. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. Neurexins and neuroligins are cell adhesion molecules present in excitatory and inhibitory synapses, and they are required for correct neuron network function. These proteins are found at the presynaptic and postsynaptic membranes. Neurexins and neurologins have an essential role in synaptic transmission. Altered neuronal connections during the development of the human nervous system could constitute the basis of the etiology of numerous cases of autism spectrum disorders. Neuroligin-1 / NLGN1 is a neuronal cell surface protein which is involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Neuroligin-1 / NLGN1 seems to play role in formation or maintenance of synaptic junctions. It triggers the de novo formation of presynaptic structures and may be involved in specification of excitatory synapses.
参考文献
Meins,M. et al., 2005, Am J Med Genet A.  132A (1): 84-9.
Ylisaukko-oja,T. et al., 2005, Eur J Hum Genet. 13 (12): 1285-92.
Kelai,S. et al., 2008, Neuroreport. 19 (7): 751-5.
Calahorro,F. et al., 2009, J Vis Exp (34).

包装：50ug

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