重组人 Fn14 / TNFRSF12A 蛋白|Fn14 / TNFRSF12A Protein|生产厂家|价格

Fn14 / TNFRSF12A蛋白产品信息
产品名称：重组人 Fn14 / TNFRSF12A 蛋白|Fn14 / TNFRSF12A Protein|生产厂家|价格
别名: CD266, FN14, TWEAKR
表达方式: 
A DNA sequence encoding the human TNFRSF12A isoform 1 (Q9NP84-1) extracellular domain (Glu 28-Trp 79) was fused with the Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

Fn14 / TNFRSF12A蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: The recombinant human TNFRSF12A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 313 amino acids and has a calculated molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTNFRSF12A/Fc monomer is approximately 37 kDa.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Fn14 / TNFRSF12A蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Fn14 / TNFRSF12A蛋白背景综述
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. TNFRSF12 is the tiniest member of the TNF receptor superfamily and has only one cysteine rich region in its extracellular domain. The TNFRSF12A cytoplasmic domain holds one TRAF binding motif which binds TRAFs 1, 2, and 3. TNFRSF12A binds its ligand TWEAK/TNFSF12A with high affinity to initiate a signal transduction cascade which subject to the cell type, causes different cellular responses such as cell death, cell proliferation, and angiogenesis. The gene for TNFRSF12A was initially recognized as a fibroblast growth factor inducible immediate early response gene Fn14 in mouse NIH 3T3 fibroblasts. Fn14 can be detected in heart, placenta, kidney, lung, skeletal muscle, pancreas, brain and liver. It is the weak inducer of apoptosis in some cell types. Fn14 promotes angiogenesis and the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.
参考文献
Burkly LC. et al., 2011, Adv Exp Med Biol. 691:305-22.
Huang M. et al., 2011, Carcinogenesis. 32(11):1589-96.
Dharmapatni AA. et al., 2011, Arthritis Res Ther. 13(2):R51.

包装：50ug

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