重组野猪 Transferrin / TF 蛋白|Transferrin Protein|技术资料|价格

Transferrin / TF蛋白产品信息
产品名称：重组野猪 Transferrin / TF 蛋白|Transferrin Protein|技术资料|价格
别名: TF
表达方式: A DNA sequence encoding the pig (Sus scrofa) transferrin (NP_001231582.1) (Met 1- Thr 715) was fused with the human IgG1 Fc region at the C-terminus.
种属: Sus scrofa (Pig)
表达宿主: Human Cells

Transferrin / TF蛋白质控指标
纯度: > 88 % as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its ability to bind human His-TFRC (cat: 11020-H07H) functional ELISA.
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 22
分子量: The secreted recombinant pig (Sus scrofa) transferrin/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 935 amino acids and has a predicted molecular mass of 103 kDa. It migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Transferrin / TF蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Transferrin / TF蛋白背景综述
Transferrin, also known as Serotransferrin, Beta-1 metal-binding globulin, TF, is a secreted protein which belongs to the transferrin family. It is expressed by the liver and secreted in plasma and contains two transferrin-like domains. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to it and, as a consequence, is transported into the cell in a vesicle. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Defects in transferrin are the cause of a transferrinemia (ATRAF) which is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Transferrin is also associated with the innate immune system.
参考文献
Cheng Y, et al., 2004, Cell 116 (4): 565-76.
St. Edward's University. 2005-07-18. Retrieved 2009-04-24.
Hafenstein S, et al., 2007, PNAS. 104 (16): 6585-9.

包装：50ug

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