重组小鼠 CLEC3B / Tetranectin 蛋白|C-type lectin domain family 3, member b Protein|价格

CLEC3B / Tetranectin蛋白产品信息
产品名称：重组小鼠 CLEC3B / Tetranectin 蛋白|C-type lectin domain family 3, member b Protein|价格
别名: Tna
表达方式: A DNA sequence encoding the mouse CLEC3B (P43025) (Met 1-Val 202) was expressed, with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

CLEC3B / Tetranectin蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 22
分子量: The recombinant mouse CLEC3B consists of 188 amino acids and predicts a molecular mass of 20.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCLEC3B is approximately 25 KDa.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLEC3B / Tetranectin蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC3B / Tetranectin蛋白背景综述
Tetranectin, also known as C-type lectin domain family 3, member B (CLEC3B), is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, Tetranectin is related to the collectin family of Ca(2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds to kringle 4 in plasminogen at low levels of Ca(2+). Exon 2 encodes an alpha-helix, which is necessary and sufficient to govern the trimerization of Tetranectin by assembling into a triple-helical coiled-coil structural element. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. TN may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC). Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.
参考文献
Lorentsen RH. et al., 2000, Biochem J. 347 (1): 83-7.
Iba K. et al., 2001, Mol Cell Biol. 21 (22): 7817-25.
Iba K. et al., 2009, Wound Repair Regen. 17 (1): 108-12.
Stoevring B. et al., 2006, Scand J Clin Lab Invest. 66 (7): 577-83.
Arellano-Garcia ME. et al., 2010, Int J Mol Sci. 11 (9): 3106-21.
Mogues T. et al., 2004, J Biomed Biotechnol. 2004 (2): 73-8.

包装：50ug

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