重组小鼠 KLK11 / Kallikrein-11 蛋白|Kallikrein related-peptidase 11 Protein|厂家价格|参数

KLK11 / Kallikrein-11蛋白产品信息
产品名称：重组小鼠 KLK11 / Kallikrein-11 蛋白|Kallikrein related-peptidase 11 Protein|厂家价格|参数
别名: 2310015I08Rik, Prss20, TLSP
表达方式: A DNA sequence encoding the mouse KLK11 isoform 2 (Q9QYN3) (Met 1-Asn 276), was fused with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

KLK11 / Kallikrein-11蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 45
分子量: The secreted recombinant mouse KLK11 (pro form) comprises 243 amino acids and has a calculated molecular mass of 27.3 kDa. The apparent molecular mass of rmKLK11 is approximately 38-42 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

KLK11 / Kallikrein-11蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

KLK11 / Kallikrein-11蛋白背景综述
kallikrein-related peptidase 11 (KLK11), also known as hippostasin, trypsin-like serine protease and PRSS20, is a member of human tissue kallikrein family. It is a subgroup of serine proteases with diverse physiological functions, which is implicated in carcinogenesis and some with potential that serving as novel biomarkers for ovarian and prostate cancer and other diseases. The KLK11 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Two alternatively spliced forms exist, resulting in 250 (isoform 1) and 282 (isoform 2) amino acid sequences. Isoform 2 is identical to isoform 1, except for an inserted 32 amino acid segment. Isoform 1 is predominantly expressed in brain whereas isoform 2 is preferentially expressed in prostate.

参考文献
Yoshida S. et al., 1998, Biochim Biophys Acta. 1399: 225-8.
Yousef GM. et al., 2000,Genomics. 63: 88-96.
Mitsui S. et al., 2000, Biochem Biophys Res Commun. 272: 205-11.
Gan L. et al., 2000, Gene. 257: 119-30.
Yousef GM. et al., 2001, Endocrine Rev. 22: 184-204.
Kong WJ. et al., 2006, J Mol Med Jan. 84 (1): 29-36.

包装：10ug

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