重组人 GDNF 蛋白|Glial cell derived neurotrophic factor Protein|厂家价格|参数

GDNF蛋白产品信息

产品名称：重组人 GDNF 蛋白|Glial cell derived neurotrophic factor Protein|厂家价格|参数
别名: ATF1, ATF2, HFB1-GDNF, HSCR3
表达方式: A DNA sequence encoding the mature form of human GDNF (P39905-2) (Arg 83-Ile 185) was expressed and purified, with additional two aa (Gly& Pro) at the N-terminus.
种属: Human
表达宿主: Human Cells

GDNF Protein QC Testing
纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
生物活性:
Measured by its ability to bind biotinylated Human GFRa1
-His in functional ELISA.
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly
分子量: The recombinant human GDNF consists of 105 amino acids and predicts a molecular mass of 15.1 KDa. It migrates as approximately 18 KDa band in SDS-PAGE under reducing conditions.
缓冲液: 
Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
 
GDNF Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
GDNF蛋白背景综述
Glial cell derived neurotrophic factor (GDNF) belongs to the GDNF family of ligands(GFL). It is a founding member of GFL. GFL comprises four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN) and plays a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. GDNF is a highly conserved neurotrophic factor. It plays a key role in the promotion of the survival of dopaminergic neurons. The recombinant form of this protein promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. GDNF has been taken as a potent survival factor for central motoneurons and it can cause two Parkinson's disease clinical trial and a number of animal trials. GDNF may be a new target for drug addiction and alcoholism treatment.
参考文献
Oppenheim RW. et al., 1995, Nature. 373 (6512): 344-6.
Tomac A. et al., 1995, Nature. 373 (6512): 335-9.
Schindelhauer D. et al., 1996, Genomics. 28 (3): 605-7.
Carnicella S. et al., 2008, Proc Natl Acad Sci . 105 (23): 8114-9.

包装：10ug

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