重组小鼠 TWSG1 蛋白|Twisted gastrulation homolog 1 (Drosophila) Protein|厂家价格|现货

WSG1蛋白产品信息

产品名称：重组小鼠 TWSG1 蛋白|Twisted gastrulation homolog 1 (Drosophila) Protein|厂家价格|现货
别名: 1810013J15Rik, 9030422N06Rik, AW552143, D17Ertd403e, Tsg, Twg
表达方式: A DNA sequence encoding the mouse TWSG1 (Q9EP52) (Met 1-Phe 222) was expressed, with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

TWSG1 Protein QC Testing
纯度: > 93 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 25
分子量: The secreted recombinant mouse TWSG1 comprises 209 amino acids and has a calculated molecular mass of 23.6kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 34 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TWSG1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TWSG1蛋白背景综述
TWSG1 is a member of the twisted gastrulation protein family. Expression of TWSG1 is found throughout mouse and human development. Overexpression of TWSG1 in transgenic mice under the control of the cartilage-specific promoter significantly reduces collagen type 10 expression in the growth plates of transgenic embryos. TWSG1 is a secreted binding protein for various bone morphogenetic proteins (BMP). Depending upon the circumstances it may function as a bone morphogenetic protein signalling agonist or antagonize these activities. TWSG1 can dislodge latent bone morphogenetic proteins and thus provides a permissive signal that allows high BMP signaling in the embryo. Activities of TWSG1 and complexed bone morphogenetic proteins are influenced also by binding of another regulatory protein, BMPER, which may function to concentrate diffusible complexes between TWSG1 and bone morphogenetic proteins. TWSG1 may be involved in dorsoventral axis formation. It seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.
参考文献
Tzachanis D. et al., 2007, J Immunol. Blood. 109 (7): 2944-52.
Tanno T. et al., 2009, Blood. 114 (1): 181-6.
Kauvar EF. et al., 2011, Mol Genet Metab. 102 (4): 470-80.

包装：50ug

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查询关键词：重组小鼠 TWSG1 蛋白，Twisted gastrulation homolog 1 (Drosophila) Protein，厂家价格，现货，原料药，大包装定制，现货促销，医药中间体，科学仪器，实验室耗材，生化试剂，创赛中国,细胞因子
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