重组大鼠 NINJURIN / Ninjurin-1 / NINJ1 蛋白|Ninjurin 1 Protein|生产厂家|参数

NINJURIN / Ninjurin-1 / NINJ1蛋白产品信息
产品名称：重组大鼠 NINJURIN / Ninjurin-1 / NINJ1 蛋白|Ninjurin 1 Protein|生产厂家|参数

别名: NINJ1
表达方式: A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.
种属: Rat
表达宿主: Human Cells

NINJURIN / Ninjurin-1 / NINJ1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: The recombinant rat NINJ1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 340 amino acids and has a calculated molecular mass of 37 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rat NINJ1/Fc monomer is approximately 50 kDa due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NINJURIN / Ninjurin-1 / NINJ1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NINJURIN / Ninjurin-1 / NINJ1蛋白背景综述
NEIL1 belongs to the DNA glycosylases family. DNA glycosylases are enzymes that participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. They initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction. NEIL1 acts as DNA glycosylase that recognizes and removes damaged bases. It has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. NEIL1 also has marginal activity towards 8-oxoguanine and AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. It cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. NEIL1 has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
参考文献
Zhang QM. et al., 2005, DNA Repair. 4 (1): 71-9.
Mokkapati SK. et al., 2004, Biochemistry. 43 (36): 11596-604.
Shinmura K. et al., 2005, Carcinogenesis. 25 (12): 2311-7.
Doublié S. et al., 2004, Proc Natl Acad. 101 (28): 10284-9.

包装：20ug

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