ADIPOQ/ ACDC蛋白产品信息
别名: ADIPOQ, ACDC, ACRP30, APM1, GBP28
表达方式:
A DNA sequence encoding the human ADIPOQ (Q15848) (Met1-Asn244) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
ADIPOQ/ ACDC Protein QC Testing
纯度: >97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 19
分子量:
The recombinant human ADIPOQ /Fc is a disulfide-linked homodimer. The reduced monomer comprises 467 amino acids and has a predicted molecular mass of 51.6 kDa. The apparent molecular mass of the protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
ADIPOQ/ ACDC Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
ADIPOQ/ ACDC蛋白背景综述
Adiponectin (ADIPOQ), also known as Adipocyte, C1q and collagen domain-containing protein, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, gelatin-binding protein, ADIPOQ and ACDC, is a secreted protein which contains oneC1q domain and onecollagen-like domain. Adiponectin/Acrp30/ADIPOQ is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin/Acrp30/ADIPOQ stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin/Acrp30/ADIPOQ antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Adiponectin/Acrp30/ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
参考文献
Maeda K. et al., 1996, Biochem Biophys Res Commun. 221: 286-9.
Saito K. et al., 1999, Gene. 229: 67-73.
Yamauchi T. et al., 2001, Nat Med. 7: 941-6.
Zhang Z. et al., 2004, Protein Sci. 13: 2819-24.
Takahashi M. et al., 2000, Int J Obes Relat Metab Disord. 24: 861-8.
规格：50ug
关 键 词：Adiponectin / Acrp30 / ADIPOQ Protein,参数,产品详情，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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