Mouse WIF1 / WIF-1 Protein |生产厂家|参数

WIF1 / WIF-1蛋白产品信息

别名: Wif1
表达方式: A DNA sequence encoding the mouse WIF1 (Q9WUA1) (Met1-Trp379) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

WIF1 / WIF-1 Protein QC Testing

纯度: > 93 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 29
分子量: The recombinant mouse WIF1 comprises 362 amino acids and has a predicted molecular mass of 39.8 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

WIF1 / WIF-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

WIF1 / WIF-1蛋白背景综述

WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 also is a tumor suppressor, and has been found to be epigenetically silenced in various cancers, specifically in nonfunctioning pituitary tumors. WIF1 gene has been tested for association to diseases, proposed to participate in pathway (Wnt signaling pathway) and processes (signal transduction, multicellular organismal development, Wnt receptor signaling pathway). WIF1 are expected to have molecular function (protein tyrosine kinase activity) and to localize in various compartments (extracellular space, extracellular region).

参考文献

Shepelev MV. et al., 2006, Mol Gen Mikrobiol Virusol. (4): 3-7.
Lin YC. et al., 2006, Biochem Biophys Res Commun. 341 (2): 635-40.
Queimado L. et al., 2007, Genes Chromosomes Cancer. 46 (3): 215-25.

规格：50ug

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