Rat TNFRSF11A Protein|技术资料|产品详情|价格

TNFRSF11A蛋白产品信息

别名: RGD1563614
表达方式: A DNA sequence encoding the rat TNFRSF11A (XP_573424.2) extracellular domain (Met 1-Pro 213) was fused with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

TNFRSF11A Protein QC Testing

纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 31
分子量: The secreted recombinant rat TNFRSF11A comprises 194 amino acids and predicts a molecular mass of 21.5 kDa. The apparent molecular mass of the rat TNFRSF11A is approximately 32 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF11A Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF11A蛋白背景综述

TNFRSF11A, also known as CD265, contains 4 TNFR-Cys repeats and belongs to the TNF-receptor superfamily. TNFRSF11A has an ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. TNFRSF11A can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It is also an essential mediator for osteoclast and lymph node development. Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

参考文献

Darnay B G. et al., 1998, J Biol Chem. 273 (32): 20551-5.
Darnay B G. et al., 1999, J Biol Chem. 274 (12): 7724-31.
Galibert L. et al., 1998, J Biol Chem. 273 (51): 34120-7.

规格：100ug

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