Mouse TFPI2 / PP5 Protein|产品详情|参数|价格

TFPI2 / PP5蛋白产品信息

别名: TFPI2
表达方式: A DNA sequence encoding the mouse TFPI2 (O35536) (Met1- Lys211) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

TFPI2 / PP5 Protein QC Testing

纯度: > 83 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 23
分子量: 
The recombinant mouse TFPI2 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 430 amino acids and has a predicted molecular mass of 48.4 KDa. The apparent molecular mass of the protein is approximately 53 KDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS,pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TFPI2 / PP5 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TFPI2 / PP5蛋白背景综述

Mouse tissue factor pathway inhibitor-2 ( TFPI-2 ), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor ( TFPI ). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 is highly abundant in the full-term placenta and widely expressed in various ***** human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. TFPI-2 inhibits a broad spectrum of serine proteinases almost exclusively through its first Kunitz-type domain, such as the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

参考文献

Sierko E. et al., 2007, Semin Thromb Hemost. 33 (7): 653-9.
Yohei Miyagi. et al., 1994, J Biochem Vol. 116 (5): 939-42.
Hitendra S. et al., 2005, Thrombosis and Haemostasis. 94 (6): 1122-30.
Guo H. et al., 2007, BMC Mol Biol. 3 (8):110.

规格：10ug

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