Mouse CNTN2 / TAG-1 Protein|产品详情|价格|参数

CNTN2 / TAG-1蛋白产品信息

别名: Tax, CNTN2
表达方式: A DNA sequence encoding the mouse CNTN2 (Q61330) (Gln31- Glu 1013) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

CNTN2 / TAG-1 Protein QC Testing

纯度: >97% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 31
分子量: The recombinant mouse CNTN2 comprises 994 amino acids and has a predicted molecular mass of 108.7 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CNTN2 / TAG-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CNTN2 / TAG-1蛋白背景综述

Contactin 2 (CNTN2), also known as TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, is a member of the contactin subfamily belonging to the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type I?II domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. CNTN2 thus plays an important role in cell adhesion, neurite outgrowth and axon guidance in the developing nervous system. The study data have suggested that TAG1-mediated cell-cell contact is formed by cis-assisted trans-binding. Association of TAG1 with Caspr2 (contactin-associated protein 2) is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. In addition, CNTN2 is also involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

参考文献

Hasler T H. et al., 1993, Eur J Biochem. 211: 329-39.
Milev P. et al., 1996, J Biol Chem. 271: 15716-23.
Rickman DS. et al., 2001, Cancer Res. 61: 2162-8.
Traka M. et al., 2003, J Cell Biol. 162: 1161-72.
Kunz B. et al., 2001, J Biol Chem. 277: 4551-7.

规格：50ug

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