Canine RBP4 Protein|技术资料|厂家价格

RBP4蛋白产品信息

别名: RBP4
表达方式: A DNA sequence encoding the canine RBP4 (F1PQI4) (Met1-Leu201) was expressed with a C-terminal polyhistidine tag.
种属: Rat
表达宿主: Human Cells

RBP4 Protein QC Testing

纯度: >94% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 19
分子量: The recombinant canine RBP4 comprises 194 amino acids and has a predicted molecular mass of 22.4 kDa. The apparent molecular mass of the protein is approximately 23 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

RBP4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

RBP4蛋白背景综述

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. In addition, RBP4 is recently identified as an adipokine whose dysregulation is closely associated with the pathogenesis of insulin resistance and type 2 diabetes, as well as obesity.

参考文献

Colantuoni V. et al., 1983, Nucleic Acid Res. 11: 7769-76.
Loredana Q. et al., 2002, J Biol Chem. 277:30191-7.
Zanotti G. et al., 2004, Vitamins and Hormones. 69: 271-95.
Cho YM. et al., 2006, Diabetes Care. 29: 2457-61.
Balagopal P. et al., 2007, J Clin Endocirnol Metab. 92: 1971-4.

规格：50ug

关 键 词：Canine RBP4 Protein,技术资料,厂家价格，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家

CANSPEC品质提供的Canine RBP4 Protein|技术资料|厂家价格性能**，其优良的品质满足您不同实验的多种需求。

本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com