EFNB1 / Ephrin-B1蛋白产品信息
别名: EFNB1, Eplg2, Lerk2
表达方式:
A DNA sequence encoding the rat EFNB1 (P52796) (Met1-Thr229) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells
EFNB1 / Ephrin-B1 Protein QC Testing
纯度: > 98 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 25
分子量:
The recombinant rat EFNB1 comprises 446 amino acids and predicts a molecular mass of 49.4 kDa. The apparent molecular mass of the rat EFNB1 is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
EFNB1 / Ephrin-B1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EFNB1 / Ephrin-B1蛋白背景综述
The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. ephrin-B1, also known as LERK-2, ELK-L, EFL-3, Cek5-L, and STRA-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-B1 has been shown to bind EphA3, EphB1, EphB2, EphB3, and EphB4. The extracellular domains of human and mouse ephrin-B1 share 94% amino acid identity.
参考文献
Cerretti DP. et al., 1995, Mol Immunol. 32 (16): 1197-205.
Gale NW. et al.,1996, Neuron.17 (1): 9-19.
Flanagan J. et al., 1998, Annual Review of Neuroscience. 21: 309-45.
Holder N. et al., 1999, Development. 126 (10): 2033-44.
Wilkinson DG. et al., 2001, Nat. Rev. Neurosci. 2 (3): 155-64.
Murai KK. et al., 2003, Journal of Cell Science. 116 (14): 2823-32.
规格：200ug
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