SIGLEC5 Protein|SIGLEC5蛋白质|技术资料|价格

SIGLEC5蛋白产品信息

别名: SIGLEC5, CD33L2, OBBP
表达方式: 
A DNA sequence encoding the human SIGLEC5 (O15389) (Met1-Thr 434) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

SIGLEC5 Protein QC Testing

纯度: >90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 17
分子量: 
The recombinant human SIGLEC5 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 659 amino acids and has a predicted molecular mass of 73.4 kDa. The apparent molecular mass of the protein is approximately 74-93 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SIGLEC5 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SIGLEC5蛋白背景综述

SIGLEC5 is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. SIGLEC5 also contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. It is highly expressed in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. As a putative adhesion molecule, SIGLEC5 mediates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

参考文献

Angata T. et al., 2006, FASEB J. 20 (12): 1964-73.
Avril T. et al., 2005, J Biol Chem. 280 (20): 19843-51.
Erickson-Miller CL. et al., 2003, Exp Hematol. 31 (5): 382-8.

规格：50ug

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