IFI30 Protein |IFI30蛋白质|生产厂家|价格

IFI30蛋白产品信息

别名: IFI30, GILT, IP30
表达方式: 
A DNA sequence encoding the human IFI30 (P13284)(Met1-Lys243 )with a C-terminal polyhistidine tag was expressed.
种属: Human
表达宿主: Human Cells

IFI30 Protein QC Testing

纯度: > 96 %

as determined by SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 27
分子量: 
The recombinant human IFI30 is a disulfide-linked homodimer. The reduced monomer comprises 217 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of the protein is approximately 31-34 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile  PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IFI30 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFI30蛋白背景综述

IFI30 is a member of the GILT family. This family contains proteins homologous to the two characterised human gamma-interferon-inducible lysosomal thiol reductase. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction. IFI30 is a lysosomal thiol reductase that can reduce protein disulfide bonds. It may facilitate the complete unfolding of proteins destined for lysosomal degradation. IFI30 also facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Meanwhile, it facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. IFI30 plays an important role in antigen processing.

参考文献

Haque MA. et al., 2002, J Exp Med. 195 (10): 1267-77.
Phan UT. et al., 2000, J Biol Chem. 275 (34): 25907-14.
Phan UT. et al., 2001, Immunogenetics. 53 (4): 342-6.

规格：20ug

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