Mouse PLAT Protein|生产厂家|价格

PLAT蛋白产品信息

别名: PLAT
表达方式: A DNA sequence encoding the mouse PLAT (P11214) (Ile309-Gln559) was was expressed with the fused Fc region of human IgG1 at the N-terminus.
种属: Mouse
表达宿主: Human Cells

PLAT Protein QC Testing

纯度: > 80 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant mouse PLAT/Fc  comprises 511 amino acids and has a predicted molecular mass of 56.4 kDa. The apparent molecular mass of the protein is approximately 57kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS,pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PLAT Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PLAT蛋白背景综述

PLAT, also known as plasminogen activator and tissue plasminogen activator, is a member of the peptidase S1 family. It is a heterodimer of chain A and chain B held by a disulfide bond. PLAT contains 1 EGF-like domain, 1 fibronectin type-I domain and 2 kringle domains. It is synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. PLAT forms heterodimer with SERPINA5. It binds to fibrin with high affinity. It also binds to annexin A2, cytokeratin-8, fibronectin and laminin. Increased activity of plasminogen activator results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of plasminogen activator results in hypofibrinolysis that can lead to thrombosis or embolism.

参考文献

Zhuo M. et al., 2000, J eurosci. 20 (2): 542-9.
Ichinose A. et al., 1986, J Clin Invest. 78 (1): 163-9.
Mateen FJ. et al., 2009, Mayo Clin Proceedings. 84 (4): 384-8.

规格：10ug

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