ASGR2 Protein|ASGR2蛋白|技术资料|实验说明

ASGR2蛋白产品信息

别名: ASGR2, CLEC4H
表达方式: 
A DNA sequence encoding the human ASGR2 (P07307-1)(Gln80-Ala311) was expressed, with an N-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells

ASGR2 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant human ASGR2 comprises 252 amino acids and has a predicted molecular mass of 28.9 kDa. The apparent molecular mass of the protein is approximately 37-42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ASGR2 Protein Usage Guide

储存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ASGR2蛋白背景综述

ASGR2 is a glycoprotein that forms the asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. ASGR2 is a subunit of the asialoglycoprotein receptor. ASGR2 mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The asialoglycoprotein receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.

参考文献

Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Zhang X. et al., 2011, Arch Virol. 156 (4): 637-45.
Guy CS. et al., 2011, Hepatology. 54 (3): 1043-50.

规格：20ug

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