Rat TIMP-1 / TIMP1 Protein|生产厂家|参数|价格

TIMP-1 / TIMP1蛋白产品信息

别名: TIMP1, Timp-1
表达方式: A DNA sequence encoding the rat TIMP1 (P01860) (Met1-Ala217) was expressed and purified.
种属: Rat
表达宿主: Human Cells

TIMP-1 / TIMP1 Protein QC Testing

纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 24
分子量: 
The recombinant rat TIMP1 consists of 194 amino acids and has a predicted molecular mass of 21.5 kDa. As a result of glycosylation, the apparent molecular mass of  the recombinant protein is approximately 28 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 50mMTris,100mMNaCl, PH7.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TIMP-1 / TIMP1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TIMP-1 / TIMP1蛋白背景综述

Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and the inducible form TIMP-1/TIMP1 is a 28 kDa glycoprotein expressed by a variety of cell types. It inhibits most MMPs except membrane-type MMP subfamily by forming non-covalent binary complex, but also interacts with the hemopexin-like (PEX) domain of pro MMP-9. TIMP-1/TIMP1 has been identified as a multifunctional molecule with divergent functions. It exhibits keratinocyte and fibroblast growth factor-like activity and acts as a cell survival factor, and additionally participates in tumor metastasis, angiogenesis, inflammatory responses, as well as CNS homeostasis. Thus, TIMP-1/TIMP1 overexpression may serve to help identify patients with particularly aggressive disease for adjuvant treatments.

参考文献

Osthues A. et al., 1992, FEBS Lett. 296: 16-20.
Aljada IS. et al., 2004, J Clin Oncol. 16: 3218-29.
Hornebeck W. 2004, Pathol Biol. 51: 569-573.
Gardner J. et al., 2003, J Neurosci Res. 74: 801-6.

规格：10ug

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