Rat CLEC4D / CLECSF8 Protein|鼠CLEC4D / CLECSF8蛋白质|参数|生产厂家

CLEC4D / CLECSF8蛋白产品信息

别名: CLEC4D, Clecsf8, Mcl
表达方式: 
A DNA sequence encoding the rat CLEC4D (Q69FH1) (Trp48-Lys218) was expressed, fused with a polyhistidine tag at the N-terminus.
种属: Rat
表达宿主: Human Cells

CLEC4D / CLECSF8 Protein QC Testing

纯度: >88 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 29
分子量: 
The recombinant rat CLEC4D is a disulfide-linked homodimer. The reduced monomer comprises 191 amino acids and has a predicted molecular mass of 22.3 kDa. The apparent molecular mass of the protein is approximately 29 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLEC4D / CLECSF8 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC4D / CLECSF8蛋白背景综述

C-type lectin domain family 4 member D, also known as C-type lectin superfamily member 8, C-type lectin-like receptor 6, CLEC4D and CLECSF8, is a single-pass type I I membrane protein which contains one C-type lectin domain. CLEC4D is expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression of CLEC4D is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. CLEC4D contains one C-type lectin domain. A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. CLEC4D functions as an endocytic receptor. It may be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.

参考文献

Drickamer K. et al., 1999, Curr Opin Struct Biol. 9 (5): 585-90.
Walker JR. et al., 2004, Biochemistry. 43 (13): 3783-92.
Zelensky AN. et al., 2005, FEBS J. 272 (24): 6179–217.
Cambi A. et al., 2009, Curr Biol. 19 (9): R375-8.

规格：50ug

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