Rat NTRK2 / TrkB Protein|生产厂家|价格

NTRK2 / TrkB蛋白产品信息

别名: NTRK2, Trkb
表达方式: 
A DNA sequence encoding the Rat NTRK2 (NP_036863) (Met1-His429) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

NTRK2 / TrkB Protein QC Testing

纯度: >92 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 32
分子量: 
The recombinant Rat NTRK2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 639 amino acids and has a predicted molecular mass of 71.5 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NTRK2 / TrkB Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NTRK2 / TrkB蛋白背景综述

TrkB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor exclusively expressed in neurons of the central nervous system. BDNF( brain-derived neurotrophic factor ) exerts biological actions through its physiological receptor TrkB which leads to the initiation of intracellular signaling cascades and different biological responses in neurons. TRKB has two distinct binding regions for BDNF within the extracellular domain with high affinity. Upon neurotrophin binding, TrkB phosphorylates itself and the downstream molecular members of the related signal pathways. TrkB has been shown to play an important role in tumorigenesis and metastasis, and mutations in this gene are associated with obesity and mood disorders. Accordingly, BDNF/TrkB signaling is thought to be a potential therapeutic target for schizophrenia.

参考文献

Klein R. et al., 1990, Cell. 64: 647-56.
Haniu M. et al., 1997, J Biol Chem. 272: 25296-303.
Haapasalo A. et al., 2002, J Biol Chem. 277: 43160-7.
Pillai A. 2008, Neurosignals. 16: 183-93.
Mas R. et al., 2007, Cancer Res. 67: 6221-9.

规格：20ug

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