Rat CDH15 / Cadherin-15 Protein|价格|参数|产品详情

CDH15 / Cadherin-15蛋白产品信息

别名: CDH15
表达方式: 
A DNA sequence encoding the rat CDH15  (Q75NI5) (Met1-Gly602) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CDH15 / Cadherin-15 Protein QC Testing

纯度: >92 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 22
分子量: 
The recombinant rat CDH15 /Fc  comprises 822 amino acids and has a predicted molecular mass of 90.6 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CDH15 / Cadherin-15 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CDH15 / Cadherin-15蛋白背景综述

Cadherin-15, also known as CDH15, belongs to the cadherin superfamily. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from Cadherin-15 are expressed in myoblasts and upregulated in myotubule-forming cells. Cadherin-15 is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM), also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome.

参考文献

Shibata T. et al., 1997, J Biol Chem. 272 (8): 5236-40.
Bornemann A. et al.,1994, Anat Rec. 239 (2): 119-25.
Donalies M. et al., 1991, Proc Natl Acad Sci. 88 (18): 8024-8.

规格：50ug

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