CDH17 / Cadherin-17 / LI-cadherin蛋白产品信息
别名: CDH17
表达方式:
A DNA sequence encoding the rat CDH17(P55281)(Met1-Met786) was expressed, fused with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells
CDH17 / Cadherin-17 / LI-cadherin Protein QC Testing
纯度: > 81 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 22
分子量:
The recombinant rat CDH17 comprises 776 amino acids and predicts a molecular mass of 86.4 kDa. The apparent molecular mass of the recombinant protein is approximately 118 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CDH17 / Cadherin-17 / LI-cadherin Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CDH17 / Cadherin-17 / LI-cadherin蛋白背景综述
Cadherins ( Calcium dependent adhesion molecules ) are a class of transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium ( Ca2+ ) ions to function. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development.
Cadherin-17, also known as Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin and CDH17, is a single-pass type I membrane protein which contains 7 cadherin domains. Cadherin-17 / CDH17 is expressed in the gastrointestinal tract and pancreatic duct. It is not detected in kidney, lung, liver, brain, adrenal gland and skin. The expression of Cadherin-17 / CDH17 is characteristic of the advanced gastric carcinoma that is associated with poor prognosis. Cadherin-17 / CDH17 is a structurally unique member of the cadherin superfamily.
参考文献
Angst B. et al., 2001, J Cell Sci. 114 (4): 629-41.
Horsfield J. et al., 2002,Mech Dev. 115 (1-2): 15-26.
Duguay D. et al., 2003, Dev Biol. 253: 309-23.
Ito R.?et al., 2005, Virchows Arch. 447 (4): 717-22.
Bayas MV. et al., 2005, Biophysical Journal.?90?(4): 1385.
Crosby CV. et al., 2005, Blood. 105 (7): 2771-6.
Hulpiau P. et al., 2009, Int J Biochem Cell Biol. 41 (2): 349-69.
规格：50ug
关 键 词：Rat CDH17 / Cadherin-17 / LI-cadherin Protein,参数,生产厂家，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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