IL2RG / CD132蛋白产品信息
别名: IL2RG
表达方式:
A DNA sequence encoding the human IL2RG(P31785) (Met1-Asn254 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
IL2RG / CD132 Protein QC Testing
纯度: > 99 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 23
分子量:
The recombinant human IL2RG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 473 amino acids and has a predicted molecular mass of 54.4 kDa. The apparent molecular mass of the protein is approximately 71 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IL2RG / CD132 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL2RG / CD132蛋白背景综述
The interleukin 2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, which binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit which are members of the type I cytokine receptor family. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. It is proposed that the γ chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors.
参考文献
Robb RJ. et al., 1981, J Exp Med. 154 (5): 1455-74.
Leonard WJ. et al., 1982, Nature. 300 (5889): 267-9.
Sharon M. et al., 1986, Science. 234 (4778): 859-63.
Tsudo M. et al., 1987, Proc Natl Acad Sci.? 84 (12): 4215-8.
Takeshita T. et al., 1992, J Immunol. 148 (7): 2154-8.
Johnson K. et al., 1994, Eur Cytokine Netw. 5 (1): 23-34.
规格：20ug
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