AGER / RAGE Protein|AGER / RAGE蛋白质|技术资料|参数

AGER / RAGE蛋白产品信息

别名: AGER
表达方式: 
A DNA sequence encoding the mature form of  human AGER (NP_001127) extracellular domain (Met1-Ala 344) was expressed and purified.
种属: Human
表达宿主: Human Cells

AGER / RAGE Protein QC Testing

纯度: > 78 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 23
分子量: 
The recombinant human AGER consists of  322 amino acids and predicts a molecular mass of 34.2 KDa. It migrates as an approximately 48 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

AGER / RAGE Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

AGER / RAGE蛋白背景综述

Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, is a single-pass type I membrane protein. AGER / RAGE contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER / RAGE mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. AGER / RAGE acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE / RAGE signaling plays an important role in regulating the production / expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction between AGER / RAGE and S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction between AGER / RAGE and S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. AGER / RAGE contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons.

参考文献

Sugaya K. et al., 1994, Genomics. 23: 408-19.
Neeper M. et al., 1992, J Biol Chem. 267: 14998-5004.
Xie T. et al., 2003, Genome Res. 13: 2621-36.
Moroz OV. et al., 2009, BMC Biochem. 10: 11.
Fang F. et al., 2010, FASEB J. 24: 1043-55.

规格：50ug

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