Mouse CDH6 / KCAD Protein|产品详情|厂家

CDH6 / KCAD蛋白产品信息

别名: CDH6
表达方式: 
A DNA sequence encoding the mouse CDH6 (P97326) (Met1- Ala615) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

CDH6 / KCAD Protein QC Testing

纯度: >90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 19
分子量: 
The recombinant mouse CDH6 comprises 616 amino acids and has a predicted molecular mass of 68.7 kDa. The apparent molecular mass of the protein is approximately 98 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CDH6 / KCAD Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CDH6 / KCAD蛋白背景综述

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. Cadherin-6(CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human cadherin-6 is synthesized as a 790 aa type I  transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa.

参考文献

Nakagawa Y. et al., 1999, J Neurosci. 19: 10877-85.
Shimazui T. et al., 2000, Eur Urol. 38: 331-8.
Suzuki SC. et al., 1997, Mol Cell Neurosci. 9: 433-47.
Inoue T. et al., 1997, Dev Biol. 183: 183-94.

规格：50ug

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