Rat IL2RG / CD132 Protein|技术资料|参数

IL2RG / CD132蛋白产品信息

别名: IL2RG
表达方式: 
A DNA sequence encoding the rat IL2RG (Q68FU6)(Met1-Ala262) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

IL2RG / CD132 Protein QC Testing

纯度: > 65 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 25
分子量: 
The recombinant rat IL2RG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 479 amino acids and predicts a molecular mass of 55 kDa. The apparent molecular mass of  the recombinant protein is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL2RG / CD132 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL2RG / CD132蛋白背景综述

The interleukin 2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, which binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit which are members of the type I cytokine receptor family. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. It is proposed that the γ chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors.

参考文献

Robb RJ. et al., 1981, J Exp Med. 154 (5): 1455-74.
Leonard WJ. et al., 1982, Nature. 300 (5889): 267-9.
Sharon M. et al., 1986, Science. 234 (4778): 859-63.
Tsudo M. et al., 1987, Proc Natl Acad Sci. 84 (12): 4215-8.
Takeshita T. et al., 1992, J Immunol. 148 (7): 2154-8.
Johnson K. et al., 1994, Eur Cytokine Netw. 5 (1): 23-34.

 规格：50ug

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