PVRL1 / HVEC / Nectin-1蛋白产品信息
别名: PVRL1
表达方式:
A DNA sequence encoding the rat PVRL1(Met1-Ala354) was expressed, fused with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells
PVRL1 / HVEC / Nectin-1 Protein QC Testing
纯度: > 97 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 31
分子量:
The recombinant rat PVRL1 comprises 335 amino acids and predicts a molecular mass of 37.6 kDa. The apparent molecular mass of the recombinant protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
PVRL1 / HVEC / Nectin-1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
PVRL1 / HVEC / Nectin-1蛋白背景综述
Poliovirus receptor-related protein 1, also known as Herpes virus entry mediator C, Nectin-1, Herpesvirus Ig-like receptor, CD111, PVRL1 and HVEC, is a single-pass type I membrane protein which belongs to the nectin family. PVRL1 acts in the initiation and maintenance of epithelial adherens junctions. Both rare and common mutations within PVRL1 make a minor contribution to disrupting the initiation and regulation of cell-to-cell adhesion and downstream morphogenesis of the embryonic face. PVRL1 can form trans-heterodimers with PVRL3 / nectin-3 and with PVRL4 / nectin-4. PVRL1 interacts (via C-terminus) with afadin (via PDZ domain). This interaction recruits PVRL1 to cadherin-based adherens junctions. PVRL1 interacts with integrin alphaV / beta3. It also interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D. PVRL1 functions as an entry receptor for these viruses. Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI), also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Defects in PVRL1 are also the cause of non-syndromic orofacial cleft type 7 (OFC7). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate.
参考文献
Lopez M. et al., 2001, J Virol. 75: 5684-91.
Reymond N. et al., 2001, J Biol Chem. 276: 43205-15.
Sakamoto Y. et al., 2006, J Biol Chem. 281:19631-44.
Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
Wollscheid B. et al., 2009, Nat Biotechnol. 27: 378-386.
规格：50ug
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