FAM19A2 Protein|FAM19A2蛋白质|生产厂家|技术资料

FAM19A2蛋白产品信息

别名: FAM19A2, TAFA2
表达方式: 
A DNA sequence encoding the human FAM19A2(Q8N3H0-1) (Ala31-His131 ) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

FAM19A2 Protein QC Testing

纯度: > 79 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant human FAM19A2/Fc  is a disulfide-linked homodimer. The reduced monomer comprises 361 amino acids and has a predicted molecular mass of 39.7 kDa. The apparent molecular mass of the protein is approximately 43 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FAM19A2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FAM19A2蛋白背景综述

FAM19A2 is a member of the FAM19/TAFA family. FAM19A2 gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. They are chemokine-like proteins. Their biological functions remain to be determined, but there are a few tentative hypotheses. They may modulate immune responses in the CNS by functioning as brain specific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. They also may represent a novel class of neurokines that act as regulators of immune nervous cells. Finally, they may control axonal sprouting following brain injury. Human FAM19A2 is 97% aa identical to mouse FAM19A2 and is expressed in the central nervous system (CNS), colon, heart, lung, spleen, kidney, and thymus.

参考文献

Parsa A. et al., 2011, Clin Transl Sci. 4(1):17-23.
Rose JE. et al., 2010, Mol Med. 16(7-8):247-53.
Trynka G. et al., 2009, Gut. 58(8):1078-83.

规格：50ug

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