ANTXR1 Protein |ANTXR1蛋白质|生产厂家|价格

ANTXR1蛋白产品信息

别名: ANTXR1 ,ATR, TEM8
表达方式: 
A DNA sequence encoding the human ANTXR1(Q9H6X2-4) (Met1-Ser321 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

ANTXR1 Protein QC Testing

纯度: > 92 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 33
分子量: 
The recombinant human ANTXR1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 530 amino acids and has a predicted molecular mass of 59.4 kDa. The apparent molecular mass of the protein is approximately 69 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ANTXR1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ANTXR1蛋白背景综述

ANTXR1 is a member of the ATR family. It contains 1 VWFA domain. ATR (Ataxia telangiectasia and Rad3 related) is closely related to ATM (Ataxia telangiectasia mutated). They belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. ANTXR1 can be detected in umbilical vein endothelial cells (at protein level). It is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. It interacts with extracellular matrix proteins and with the actin cytoskeleton. ANTXR1 mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. ANTXR1 also plays a role in the angiogenic response of cultured umbilical vein endothelial cells. It binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.Interacts with gelatin and type 1 collagen. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile.

参考文献

Chaudhary A. et al., 2012, Cancer Cell. 21 (2): 212-26.
Garlick KM. et al., 2012, Biochemistry. 51 (6): 1249-56.
St Croix B. et al., 2000, Science. 289 (5482): 1197-202.

规格：20ug

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