BPIFA2 / C20orf70 Protein|技术资料|产品详情

BPIFA2 / C20orf70蛋白产品信息

别名: C20orf70 , BPIFA2 ,SPLUNC2
表达方式: 
A DNA sequence encoding the human C20orf70 (Q96DR5)(Met1-Ile249) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

BPIFA2 / C20orf70 Protein QC Testing

纯度: > 94 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 19
分子量: 
The recombinant human C20orf70/Fc is a disulfide-linked homodimer. The reduced monomer comprises 470 amino acids and has a predicted molecular mass of 51.8 kDa. The apparent molecular mass of the protein is approximately 59 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BPIFA2 / C20orf70 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BPIFA2 / C20orf70蛋白背景综述

C20orf70 is a member of the BPI/LBP/Plunc superfamily, Plunc family. PLUNC family is composed of mucosal secretory proteins that are predicted to be structurally similar to lipid-binding and host-defense proteins including bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein. C20orf70 is expected to have molecular function (lipid binding) and to localize in extracellular region. It is a salivary protein of unknown function. C20orf70 can be detected in submandibular gland. C20orf70 gene contains 9 distinct gt-ag introns. Transcription produces 6 different mRNAs, 4 alternatively spliced variants and 2 unspliced forms. There are 2 probable alternative promotors, 3 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 3' end. 80 bp of this gene are antisense to spliced gene glopa, raising the possibility of regulated alternate expression.

参考文献

Lamesch P. et al., 2007, Genomics. 89 (3): 307-15.
Vargas PA. et al., 2008, Oral Dis. 14 (7): 613-9.
Bingle L. et al., 2009, Histochem Cell Biol. 132 (3): 339-49.

规格：50ug

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