CLEC10A / MGL1 / CD301 Protein|技术资料|现货

CLEC10A / MGL1 / CD301蛋白产品信息

别名: CLEC10A, CLECSF13, CLECSF14, HML
表达方式: 
A DNA sequence encoding the human CLEC10A (Q8IUN9-2)(Gln61-His292) was expressed, with the fused Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

CLEC10A / MGL1 / CD301 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant human CLEC10A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 492 amino acids and has a predicted molecular mass of 54.6 kDa. The apparent molecular mass of the protein is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLEC10A / MGL1 / CD301 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC10A / MGL1 / CD301蛋白背景综述

Macrophage galactose-/N-acetylgalactosamine-specific-lectin (MGL/CD301), also known as CLEC10A, a unique calcium-type (C-type) lectin, which expressed on Dendritic cells (DCs), is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). There are 2 homologues in mice: MGL1 and MGL2 (CD301a and CD301b). MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1alpha was proposed to regulate specific cellular interactions crucial to granulation tissue formation. MGL1 is a novel regulator of inflammatory monocyte trafficking to adipose tissue in response to diet-induced obesity (DIO).

参考文献

Dupasquier M. et al, 2006, J Leukoc Biol. 80(4): 838-49.
Sato K. et al, 2005, Blood. 106(1): 207-15.
Denda-Nagai K. et al, 2010, J Biol Chem. 285(25): 19193-204.
Westcott DJ. et al, 2009, J Exp Med. 206(13): 3143-56.

规格：50ug

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