CANT1 Protein|CANT1 蛋白质|生产厂家|价格

CANT1蛋白产品信息

别名: CANT1, SHAPY
表达方式: 
A DNA sequence encoding the human CANT1(Q8WVQ1-1)(Gly80-Ile401) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

CANT1 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant human CANT1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 582 amino acids and has a predicted molecular mass of 64.3 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CANT1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CANT1蛋白背景综述

CANT1(calcium activated nucleotidase 1, N-Histidine-tagged) belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Alternatively spliced transcript variants have been noted for this gene. Defects in CANT1 are the cause of desbuquois dysplasia. A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.

参考文献

Failer BU. et al., 200, J Biol Chem. 277 (40): 36978-86.
Smith TM et al., 2002, Arch Biochem Biophys. 406 (1): 105-15.
Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.

规格：10ug

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