Mouse LYVE1 / LYVE-1 Protein|生产厂家|参数

LYVE1 / LYVE-1蛋白产品信息

别名: 
LYVE1, Crsbp1, Xlkd1
表达方式: A DNA sequence encoding the mouse LYVE1 (Q8BHC0) (Met1- Gly228 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

LYVE1 / LYVE-1 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 24
分子量: 
The recombinant mouse LYVE1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 446 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LYVE1 / LYVE-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LYVE1 / LYVE-1蛋白背景综述

YVE1, also known as LYVE-1, is a type I integral membrane glycoprotein and acts as a receptor and binds to both soluble and immobilized hyaluronan. It contains 1 Link domain and mainly expressed in endothelial cells lining lymphatic vessels. LYVE1 may function in lymphatic hyaluronan transport and have a role in tumor metastasis. It may act as an hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. LYVE1 also is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. It also functions as a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding.

参考文献

Jackson DG. 2003, Trends Cardiovasc Med. 13 (1): 1-7.
Banerji S. et al., 1999, J Cell Biol. 144 (4): 789-801.
Mouta Carreira C. et al., 2001, Cancer Res. 61 (22): 8079-84.
Cursiefen C. et al., 2002, Invest Ophthalmol Vis Sci. 43 (7): 2127-35.

规格：20ug

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