Mouse PRLR / Prolactin receptor Protein|技术资料|生产厂家

PRLR / Prolactin receptor蛋白产品信息

别名: PRLR
表达方式: 
A DNA sequence encoding the mouse PRLR (P07321) (Met1- Asp229) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

PRLR / Prolactin receptor Protein QC Testing

纯度: >95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 20
分子量: 
The recombinant mouse PRLR comprises 221 amino acids and has a predicted molecular mass of 26 kDa. The apparent molecular mass of the protein is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PRLR / Prolactin receptor Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PRLR / Prolactin receptor蛋白背景综述

Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type Ⅰ cytokine receptor superfamily, and contains two fibronectin type-Ⅲ domains. PRLR is widely expressed in breast, placenta, kidney, liver and pancreas, and mainly serves as the receptor for the pituitary hormone prolactin (PRL) , a secreted hormone that affects reproduction and homeostasis in vertebrates. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. It has been shown that specific binding to PRLR can stimulate the breast cancer cells to grow and certain antagonists which bind but do not dimerize PRLR can inhibit the growth of breast cancer cells. Several isoforms have been described, and the soluble form are unable to transduce prolactin signaling.

参考文献

Somers W. et al., 1994, Nature. 372: 478-81.
Fuh G. et al., 1995, J Biol Chem. 270: 13133-7.
Kline JB. et al., 1999, J Biol Chem. 274: 35461-8.
Svensson LA. et al., 2008, J Biol Chem. 283: 19085-94.

规格：50ug

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