Rat IL13RA1 Protein|鼠IL13RA1蛋白质|产品详情|价格

IL13RA1蛋白产品信息

别名: IL13RA1
表达方式: 
A DNA sequence encoding the rat IL13RA1 (Q561K3) (Met1-Thr342) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

IL13RA1 Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 27
分子量: 
The recombinant rat IL13RA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 557 amino acids and has a predicted molecular mass of 62.9 kDa. The apparent molecular mass of the protein is approximately 91 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL13RA1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL13RA1蛋白背景综述

Interleukin 13 receptor alpha 1 (IL13 Rα1), also known as CD213A1 (cluster of differentiation 213A1), is a subunit of the IL-13 receptor, and binds IL13 with a low affinity by itself. IL-13 is capable of binding two types of receptor: the heterodimer, composed of the IL13 Rα1 and the IL4Rα , transducing the IL13 signals; and the IL13Rα2, acting as a nonsignaling "decoy" receptor. IL13 Rα1 forms a functional receptor complex for IL-13 with IL4 receptor alpha (IL4Rα), a subunit shared by IL13 and IL4 receptors, transducing an IL13-dependent proliferative signal. IL13 Rα1 has also been shown to serve as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity. The human IL13 Rα1 cDNA encodes a 427 aa residue precursor protein, and the extracellular domain is composed of three fibronectin type I II domains, D1, D2, and D3, of which the last two comprise the cytokine receptor homology modules (CRHs). Human and mouse IL13 Rα1 share 76% aa sequence identity.

参考文献

Caput D. et al., 1996, J Biol Chem. 271: 16921-6.
Hilton D.J. et al., 1996, Proc Natl Acad Sci. 93: 497-501.
Zhang JG. et al., 1997, J Biol Chem. 272: 9474-80.
Donaldson DD. et al., 1998, J Immunol. 161: 2317-24.
Orchansky PL. et al.,1999, J Biol Chem.?274?(30): 20818-25.

规格：100ug

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