IL-21R / Interleukin-21 Receptor蛋白产品信息
别名: IL21R
表达方式:
A DNA sequence encoding the rat IL21R (Q5EBB1)(Met1-Pro236) was expressed, fused with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells
IL-21R / Interleukin-21 Receptor Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 20
分子量:
The recombinant rat IL21R comprises 228 amino acids and predicts a molecular mass of 26.5 kDa. The apparent molecular mass of the recombinant protein is approximately 43-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IL-21R / Interleukin-21 Receptor Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human IL-21R/IL21R WB, ELISA IL-21R Antibody (Antigen Affinity Purified) 11483-RP02
IL-21R / Interleukin-21 Receptor蛋白背景综述
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene ( IL-4RA ). Interleukin-21 ( IL-21 ) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor ( IL-21R ) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.
参考文献
Hecker,M. et al., 2003, Genes Immun. 4?(3): 228-33.
Ettinger, R. et al., 2008, Ann Rheum Dis. 67 Suppl 3?:iii 83-6.
Fr?hlich, A. et al., 2009, Science. 324?(5934): 1576-80.
Webb, R. et al., 2009,?Arthritis Rheum. 60?(8): 2402-7.
规格：50ug
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