Rat IL13RA2 / IL13R Protein|产品详情|价格

IL13RA2 / IL13R蛋白产品信息

别名: L13RA2
表达方式: 
A DNA sequence encoding the rat IL13RA2(Q8VHK6)(Met1-Lys336) was expressed, fused with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

IL13RA2 / IL13R Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 24
分子量: 
The recombinant rat IL13RA2 comprises 324 amino acids and predicts a molecular mass of 37.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL13RA2 / IL13R Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL13RA2 / IL13R蛋白背景综述

Interleukin-13 receptor alpha2 chain(IL-13Rα2) is one of the receptor components for IL-13, a Th2 cell-derived pleiotropic immune regulatory cytokine. IL13Rα2 contains 3 fibronectin type-III domains, and binds as a monomer with high affinity to IL-13. IL-13Rα2 exists both on the cell membrane and in soluble form intracellularly which are generated from distinct transcripts. IL-13Rα2 was initially cloned from a kidney cell line and then found to be expressed in brain, spleen, liver, thymus, and also in the bone marrow, which are hemopoietic or hypervascular tissues. Soluble IL-13Rα2 was found in multiple mouse organs and was up-regulated in lungs following allergen challenge. IL-13Rα2 is expressed on certain types of cancer cells including glioblastoma, AIDS Kaposi's sarcoma, and head and neck cancer. In a IL13Rα2 transgenic mice model, the antitumor activity of IL13-PE, a receptor-directed cytotoxin was profoundly enhanced, providing elimination of established tumor in some xenografts. Comparisons of the human and murine receptors show that they are structurally conserved, share 59% aa identity.

参考文献

Kawakami K. 2005, Curr Gene Ther. 5(2): 213-23.
Tabata Y.? et al., 2007, Curr Allergy Asthma Rep. 7(5): 338-45.
Yasuhiro T. et al., 2006, The Journal of Immunology. 177: 7905-12.
Debra D Donaldson. et al., 1998, The Journal of Immunology. 161: 2317-24.

规格：100ug

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