F11R / JAM-A / JAM-1蛋白产品信息
别名: F11R, Jam1
表达方式:
A DNA sequence encoding the rat F11R (Q9JHY1) (Met1- Gly238) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells
F11R / JAM-A / JAM-1 Protein QC Testing
纯度: > 96% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Lys 27
分子量:
The recombinant rat F11R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 49.9 kDa. The apparent molecular mass of the protein is approximately 60 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
F11R / JAM-A / JAM-1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
F11R / JAM-A / JAM-1蛋白背景综述
Junctional adhesion molecule A, also known as Junctional adhesion molecule 1, Platelet F11 receptor, JAM-1, Platelet adhesion molecule 1, JAM-A, PAM-1, CD321 and F11R, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and Junctional Adhesion Molecule (JAM) family. JAM-A / CD321 is the firstly identified member of the JAM family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea.
参考文献
Williams LA. et al., 1999, Mol Immunol. 36: 1175-88.
Sobocka MB. et al., 2000, Blood. 95: 2600-9.
Babinska A. et al., 2002, Thromb Haemost. 88: 843-50.
Ostermann G. et al., 2002, Nat Immunol. 3: 151-8.
Kenneth J. et al., 2005, J Biol Chem. 280: 11665-74.
Bazzoni G. et al., 2003, Curr Opin Cell Biol. 15: 525-30.
Barton ES. et al., 2001, Cell. 104 : 441-51.
规格：50ug
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