Rat CD55 / DAF Protein |价格|实验说明

CD55 / DAF蛋白产品信息

别名: CD55, DAF, Daf1
表达方式: 
A DNA sequence encoding the rat CD55 (Q9Z0M0) (Met1-Ser371) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD55 / DAF Protein QC Testing

纯度: > 82 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 35
分子量: 
The recombinant rat CD55/Fc is a disulfide-linked homodimer. The reduced monomer comprises 578 amino acids and has a predicted molecular mass of 64.5 kDa. The apparent molecular mass of the protein is approximately 91 and 54 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD55 / DAF Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD55 / DAF蛋白背景综述

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It interferes with the functions of C3 and C5 convertases in both the classical and alternative pathways by preventing the assembly of the C3bBb complex or accelerating the disassembly of preformed convertase, and thus disrupts the cascade and protects the host cells from damage. Antigens present on the CD55/DAF constitute determinant for the Cromer blood group system. CD55/DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that CD55/DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. There are two variants of CD55 encoded by alternatively spliced transcripts, the predominant variant is a GPI-anchored membrane form ubiquitously expressed on cells exposed to plasma complement proteins, whereas a soluble form present at much lower level.

参考文献

Bergelson JM. et al., 1994, Proc Natl Acad Sci. 91: 6245-8.
Terstappen LW. et al., 1992, J Leuro Biol. 52: 652-60.
Liu J. et al., 2005, J Exp Med. 201: 567-77.
Madjd Z. et al., 2004, Clin Cancer Res. 10: 2797-803.
Mikesch JH. et al., 2007, Cell Oncol. 28: 223-32.

规格：50ug

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