Cynomolgus IL23R / IL23 Receptor Protein|技术资料|价格

IL23R / IL23Receptor蛋白产品信息

别名: IL23R
表达方式: 
A DNA sequence encoding the cynomolgus IL23R(F6XR82) (Met1-Asp353) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IL23R / IL23Receptor Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 24
分子量: 
The recombinant cynomolgus IL23R is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a calculated molecular mass of 64.9 KDa.The apparent molecular mass of cynomolgos IL23R  is approximately 92 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL23R / IL23Receptor Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL23R / IL23Receptor蛋白背景综述

IL23R, also known as IL23Receptor, is a member of the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

参考文献

Duerr RH. et al., 2006, Science. 314 (5804): 1461-3.
Cargill M. et al., 2007, Am J Hum Genet. 80 (2): 273-90.
Dubinsky MC. et al., 2007, Inflamm Bowel Dis. 13 (5): 511-5.
Tremelling M. et al., 2007, Gastroenterology. 132 (5): 1657-64.

规格：50ug

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