NRG1 (aa 2-246) Protein|NRG1(aa 2 - 246)蛋白|厂家|产品详情

NRG1蛋白产品信息

别名: NRG1, GGF, HGL, HRGA, NDF, SMDF
表达方式: 
A DNA sequence encoding the human NRG1(Q02297-isoform6) (Ser2-Lys246) was expressed.
种属: Human
表达宿主: Human Cells

NRG1 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
生物活性:
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.
The ED50 for this effect is typically 20-60 ng/mL.
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 2
分子量: 
The recombinant human NRG1  comprises 245 amino acids and has a predicted molecular mass of 26.8 kDa. The apparent molecular mass of the monomer is approximately 48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NRG1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NRG1蛋白背景综述

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

参考文献

Nicodemus KK. et al., 2010, Arch Gen Psychiatry. 67 (10): 991-1001.
Tan W. et al., 2007, J Biol Chem. 282 (33): 24343-51.
Holmes WE. et al., 1992, Science. 256 (5060): 1205-10.

规格：50ug

关 键 词：NRG1 (aa 2-246) Protein,NRG1(aa 2 - 246)蛋白,厂家,产品详情，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家

CANSPEC品质提供的NRG1 (aa 2-246) Protein|NRG1(aa 2 - 246)蛋白|厂家|产品详情性能**，其优良的品质满足您不同实验的多种需求。

本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com