Mouse GPNMB / Osteoactivin Protein|厂家|产品详情

GPNMB / Osteoactivin蛋白产品信息

别名: GPNMB, Dchil, Nmb
表达方式: 
A DNA sequence encoding the mouse GPNMB (Q99P91) (Met1- Asn502) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

GPNMB / Osteoactivin Protein QC Testing

纯度: >90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Lys 23
分子量: 
The recombinant mouse GPNMB comprises 490 amino acids and has a predicted molecular mass of 54.9 kDa. The apparent molecular mass of the protein is approximately 96 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GPNMB / Osteoactivin Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GPNMB / Osteoactivin蛋白背景综述

GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.A

参考文献

Pahl MV. et al., 2010, Clin J Am Soc Nephrol. 5 (1): 56-61.
Abdelmagid SM. et al., 2008, Exp Cell Res. 314 (13): 2334-51.
Haralanova-Ilieva B. et al., 2005, J Hepatol. 242 (4): 565-72.
Abdelmagid SM. et al., 2007, J Cell Physiol. 210 (1): 26-37.
Furochi H. et al., 2007, J Med Invest. 54 (3-4): 248-54.

规格：50ug

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